This Viewpoint suggests that infection control guidelines should be re-evaluated to account for the predominance of small particles within infectious aerosols. Protective devices available to health-care workers have a range of protection, increasing from surgical masks to filtering facepiece respirators to powered air-purifying respirators. Although these are indicated for close encounters, their limitations highlight the need for improved administrative controls, such as more rapid diagnosis and isolation, and the development of vaccines and treatments. These data support calls for the recognition of aerosol (ie, traditional airborne) transmission of SARS-CoV-2. This could facilitate the use of enhanced dilution and directional ventilation and other environmental control options—eg, air disinfection with ultraviolet germicidal irradiation, which might be especially helpful in congregate settings such as nursing homes. Implementation of improved infection control measures could prevent future morbidity and mortality among health-care workers.